Self-Assembling Peptide P11-4 in Biomimetic Enamel Regeneration
SAP P11-4 and enamel regeneration
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As the outer layer of teeth, enamel has to tolerate a range of physical and chemical challenges. Teeth pathologies are commonly manifested as gradual demineralization, which leads to mechanical failure and cavitation. Caries is traditionally "treated" by drilling and filling, which involves the replacement of injured tissue with foreign material. Such invasive therapy and the removal of major portions of the tooth weakens and destabilises the tooth, resulting in the eventual failure of the filling. Traditional drilling and filling methods have been superseded by numerous regeneration and remin...
As the outer layer of teeth, enamel has to tolerate a range of physical and chemical challenges. Teeth pathologies are commonly manifested as gradual demineralization, which leads to mechanical failure and cavitation. Caries is traditionally "treated" by drilling and filling, which involves the replacement of injured tissue with foreign material. Such invasive therapy and the removal of major portions of the tooth weakens and destabilises the tooth, resulting in the eventual failure of the filling. Traditional drilling and filling methods have been superseded by numerous regeneration and remineralization processes since the introduction of minimal intervention dentistry. If nucleation sites are there for minerals from saliva or other therapies for precipitation, they can aid in faster remineralization in early enamel lesions. A self-assembling peptide, P11-4, has been demonstrated to permeate into early lesions and trigger the formation of new hydroxyapatite crystals. Various researches have indicated that self-assembling peptide P11-4 has a clinically beneficial effect in the regression of early enamel lesions, making it a viable strategy for biomimetic remineralization.
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