Selective Relaxant Binding Agent
Broschiertes Buch

Selective Relaxant Binding Agent

Sugammadex, Rocuronium Bromide

Herausgegeben: Mattheus, Dagda Tanner
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Selective Relaxant Binding Agents (SRBAs) are a new class of drugs that selectively encapsulates and binds neuromuscular blocking agents (NMBAs). The first drug introduction of an SRBA is sugammadex. Sugammadex is a modified gamma cyclodextrin that specifically encapsulates and binds the aminosteroid NMBAs: rocuroniumvecuroniumancuronium. SRBAs exert a chelating action that effectively terminates an NMBA ability to bind to nicotinic receptors.The discovery of SRBA as a new class of drug is the result of work done by Organon laboratories at the Newhouse research site in Scotland. Cyclodextrins ...