Role of the Subthalamic Nucleus in the basal ganglia network
Rachida Ammari
Broschiertes Buch

Role of the Subthalamic Nucleus in the basal ganglia network

Electrophysiological study in vitro in the normal and parkinsonian mice

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The Subthalamic Nucleus (STN) is a crucial component of the basal ganglia circuitry that participates in the control of motor behaviour. During Parkinson s disease (PD), pathological activities emerges in the STN and its targets structures (Globus Paallidus and Substantia Nigra Pars Reticulata). Those activities are correlated, rhythmic and coherent at both beta (13-30Hz) and tremor frequency (4-10Hz). Its lesion or its high frequency stimulation in parkinsonian patients and in animal models remarkably attenuates the motor symptoms of PD. How this excitatory structure interacts with the rest o...