Role of PPAR agonist in Cerebral Ischemia Reperfusion Injury

Role of PPAR agonist in Cerebral Ischemia Reperfusion Injury

Effect of PPAR agonist on I/R injury

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Objective: Present study was designed to investigate effect of gemfibrozil on I/R. Experimental: I/R in rats were induced by bilateral carotid artery occlusion (30 min) and followed by reperfusion (2 hrs). Results and Discussion: Gemfibrozil treated rats demonstrated significant reduction in infarct sizes (P 0.05) when compared with I/R group of rats, suggested that gemfibrozil markedly attenuated I/R injury. Gemfibrozil treatment demonstrated a significant decreased in malondialdehyde (P 0.01), and significant increased was observed in level of reduced glutathione (P 0.01), superoxide dismuta...