Role of neuronal IGF-1R signaling in Alzheimer¿s disease
Moritz M. Hettich
Broschiertes Buch

Role of neuronal IGF-1R signaling in Alzheimer¿s disease

Involvement in development and progression

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Brains from patients with AD reveal a markedly down regulaton of IGF-1R expression and these changes progress with severity of neurodegeneration. To investigate the role of neuronal IGF-1R signaling in AD a neuron-specific IGF-1R deficient mice were generated and were crossed with mice expressing mutated human APP which was found in a Swedish family with early-onset AD. The offsprings of these mice were analysed. Kaplan-Meier-analysis after 60 weeks of observation revealed that nIGF-1R knockout mice were protected against premature mortality of AD mice and showed reduced Abeta accumulation. In...