Role of Hsp(s) in Chemotherapeutic Drug Resistance in Cancer Cells
Aanchal Sharma
Broschiertes Buch

Role of Hsp(s) in Chemotherapeutic Drug Resistance in Cancer Cells

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Due to substantial technical improvements, clinical application of heat as a co-adjuvant in cancer treatment is acquiring new interest. The effect of hyperthermia on hepatoma cell lines Hep3B (p53 defective) and HepG2 (p53 wild type) when investigated led to an interesting observation that Hep3B cells are more susceptible to heat stress than HepG2 cells. In addition, heat-induced carboplatin resistance was observed in HepG2 cells only. To investigate the reasons, heat shock response was explored and it was observed that heat stress augmented heat shock protein 70 (Hsp70) expression levels in H...