Role of AgNORs' Analysis in Urine Cytology

Role of AgNORs' Analysis in Urine Cytology

A study of the value of silver stained Nucleolar organizer regions in the diagnosis of urothelial carcinoma

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The silver-staining technique for nucleolar organizer regions (AgNOR) of Ploton et al, as popularized by Crocker et al, is being widely used for evaluation of nucleolar function, especially in neoplasia. This work is carried out to evaluate the usefulness of AgNOR technique in the differentiation between benign and malignant lesions in urine cytology, and to evauate the correlation of AgNOR count and morphology with tumor grade and patients sex. Urine samples from sixty-four patients were centrifuged, deposits smeared on slides and stained with Hematoxylin and Eosin (H&E) and AgNOR stain. The ...