Broschiertes Buch

Replicating Vaccines

A New Generation

Herausgegeben: Dormitzer, Philip R.; Mandl, Christian W.; Rappuoli, Rino

Beschreibung

Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines.

This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.

Produktdetails

• Birkhäuser Advances in Infectious Diseases
• Verlag: Springer / Springer Basel / Springer, Basel
• Artikelnr. des Verlages: 978-3-0348-0316-8
• 2011
• Seitenzahl: 464
• Erscheinungstermin: 2. Januar 2013
• Englisch
• Abmessung: 235mm x 155mm x 25mm
• Gewicht: 698g
• ISBN-13: 9783034803168
• ISBN-10: 3034803168
• Artikelnr.: 36858800

Rezensionen

From the reviews:
"This book introduces the current thinking on rational attenuation and this important theme runs through the book, tying the chapters together very nicely. ... Given the renaissance in vaccinology this is a timely volume which ... makes judicious use of selected examples to highlight key aspects of this burgeoning field. This book is both a useful primer for students and a thought-provoking read for researchers in this field." (Paul Duprex, Microbiology Today, November, 2011)