Renal Medullary Circulation
Louise EvansAllen Cowley
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Renal Medullary Circulation

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The two kidneys of mammalian organisms receive around 25 % of the cardiac output at rest, of which only ~7 % is distributed to the renal medulla. Despite the low blood flow to the renal medulla, small changes in perfusion to the region can have profound effects on urine-concentrating ability and the excretion of sodium, which in turn affects the chronic regulation of body fluid volumes and arterial blood pressure. Importantly, we know that if blood flow to the renal medulla is not tightly regulated, sodium and water homeostasis is impaired and medullary hypoxia develops. The resultant injury i...