Regulation and Function of nTrip6, the Nuclear Isoform of the LIM-domain Protein Trip6, in Skeletal Muscle Differentiation
Oliver Dahley
Broschiertes Buch

Regulation and Function of nTrip6, the Nuclear Isoform of the LIM-domain Protein Trip6, in Skeletal Muscle Differentiation

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Muscle tissue in higher vertebrates consists of slow twitch (type I) and fast twitch (type II) muscle fibers. This fiber type identity is determined by the set of genes, either type I/slow or type II/fast that the fiber expresses. One of the main transcription factors controlling fiber type identity is Mef2c, which drives the expression of type I/slow genes. However, Mef2c is expressed in both type I/slow and type II/fast fibers. Thus, its activity needs to be differentially regulated in the two different fiber types. Here I report that nTrip6, the nuclear isoform of the LIM-domain protein Tri...