Real-Space Methods to Solve Protein Structures
James Foadi
Broschiertes Buch

Real-Space Methods to Solve Protein Structures

Improved Density-Modification Techniques for Phasing and Phase Extension in Protein Crystallography.

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This book reproduces work written for a PhD thesis. It introduces new theoretical methods for the solution of protein structures through the processing and interpretation of crystallographic data coming from high-resolution X-ray diffraction experiments. Only data for the native protein are used, i.e. the procedure here explained and tested implies ab initio solution. This method has been implemented in a computer package, ACORN, whose main underlying concept is that a proper structural fragment, equivalent to 5-10% of the structure being studied, can give rise to enough information to start a...