Rational drug design at the blood-brain barrier
Sergey Shityakov
Broschiertes Buch

Rational drug design at the blood-brain barrier

Rational drug design and testing applied to blood-brain barrier permeation of lead and cyclodextrin-formulated compounds

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In order to be efficient as a therapeutic agent, CNS (central nervous system)-acting drugs must cross the blood-brain barrier (BBB) and enter into the brain. The existing and new biomedical approaches for the rational design of novel CNS-active nanocarriers and prodrugs to improve drug delivery play an important role by enhancing drug passive and active BBB transport. These drug delivery vectors can be applied for the treatment of many neurologic conditions, including Alzheimer's or Parkinson's diseases, neuroinfections (meningitis and encephalitis), hemorrhagic and ischemic stroke, and trauma...