Racemic Crystallography
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Racemic crystallography is a recently-developed technique of structural biology, which appears capable of producing certain protein crystals. The process was first proposed by UCLA structural biologist Todd Yeates in 1995, who suggested that a racemic mixture of proteins would crystallize more readily than each component alone. The process of mixing proteins made of D-amino acids with the more readily available L-amino acid-containing proteins appears straightforward,...
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Racemic crystallography is a recently-developed technique of structural biology, which appears capable of producing certain protein crystals. The process was first proposed by UCLA structural biologist Todd Yeates in 1995, who suggested that a racemic mixture of proteins would crystallize more readily than each component alone. The process of mixing proteins made of D-amino acids with the more readily available L-amino acid-containing proteins appears straightforward, but it took a decade to overcome the obstacle that D-amino acids cannot be isolated in the laboratory. The obstacle was gradually overcome by laboratories which developed methods of chemically synthesizing D-amino proteins. By 2008 the United States National Institute of General Medical Sciences was able to synthesize about 300 such amino acids.
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