Pseudo Random Arterial Modulation (PRAM)

Pseudo Random Arterial Modulation (PRAM)

Novel MRI Approach to Measure Blood Flow and Transit Times

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The Pseudo Random Arterial Modulation (PRAM) is a non-invasive MRI based method to measure blood flow. It does not require any contrast agent but rather uses water protons in the body as the contrast. PRAM is based on a pseudo random sequence of inversions and non-inversions of the arterial blood using radio frequency (RF) pulses at a labeling plane inferior to the imaging plane. A series of images are taken at the imaging plane and flow reconstructed from the transit time measurements. PRAM does not require separate control and label acquisition as is common in Arterial Spin Labeling (ASL) bu...