Proprotein Convertase 2
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Proprotein convertase 2 (PC2) is a serine protease and proprotein convertase It is also referred to as "prohormone convertase 2". PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates. To generate the bioactive form of insulin (and many other peptides), a second step involving the removal of C-terminal ba...
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Proprotein convertase 2 (PC2) is a serine protease and proprotein convertase It is also referred to as "prohormone convertase 2". PC2, like proprotein convertase 1 (PC1), is an enzyme responsible for the first step in the maturation of many neuroendocrine peptides from their precursors, such as the conversion of proinsulin to insulin intermediates. To generate the bioactive form of insulin (and many other peptides), a second step involving the removal of C-terminal basic residues is required; this step is mediated by carboxypeptidases E and/or D. PC2 plays only a minor role in the first step of insulin biosynthesis, but a greater role in the first step of glucagon biosynthesis compared to PC1.
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