Proprotein Convertase 1
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Proprotein convertase 1, also called "prohormone convertase 1" and "prohormone convertase 3" and usually abbreviated as PC1/3, is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleave after a single arginine. It binds...
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Proprotein convertase 1, also called "prohormone convertase 1" and "prohormone convertase 3" and usually abbreviated as PC1/3, is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleave after a single arginine. It binds to a protein known as proSAAS, which also represents its endogenous inhibitor. PC1 is synthesized as a 99kDa proform quickly converted to an 87 kDa major active form, which itself is nearly completely cleaved to a 66 kDa active form within neuroendocrine cells.
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