Probability Models for DNA Sequence Evolution

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Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability? To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigati...

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From the first edition:

"This book serves as an introduction to, and a compilation of, results in the new and growing field of probability theory for DNA evolution. The author is a probabilist, but he has made an effort to appeal to biologists and mathematicians alike. Biologists will find in this book those methods used for studying DNA variability that go beyond straightforward applications of statistics and require genuine mathematical insight into the underlying mechanisms. The example data are real and the driving motivation is to understand these truthfully. Mathematicians will find in this book not an attempt to develop some abstract theory, but rather a kaleidoscopic collection of ideas and methods invented to attack a

From the reviews:This book serves as an introduction to, and a compilation of, results in the new and growing field of probability theory for DNA evolution. The author is a probabilist, but he has made an effort to appeal to biologists and mathematicians alike. Biologists will find in this book those methods used for studying DNA variability that go beyond straightforward applications of statistics and require genuine mathematical insight into the underlying mechanisms. The example data are real and the driving motivation is to understand these truthfully. Mathematicians will find in this book not an attempt to develop some abstract theory, but rather a kaleidoscopic collection of ideas and methods invented to attack a common problem. The

emphasis is on catching the main ideas in down-to-earth calculations; continuum models and more sophisticated methods from analysis are avoided. The book starts with the Wright-Fisher model for neutral selection in a constant population, and then builds and varies on this in Chapters 1--3 by adding the effects of mutation, recombination, selection, nonconstant population sizes and spatial structure. Chapter 4 is devoted to statistical tests for detecting departures from the neutral model and Chapter 5 discusses the large-scale structure of the DNA such as the size and number of chromosomes, inversions, translocations and duplications. This book will serve as a useful guide to this new and exciting field and an inspiration even for the more experienced readers.--Mathematical Reviews"With numerous interspersed example datasets from the primary literature, this book offers a brief introduction to models of both long-term and short-term DNA sequence evolution, with emphasis on the latter...Diverse audiences will find much of the value in this concise book. The author's rigor and ability to embed material in a broader mathematical context will appeal to quantitative readers with little background in biology...The book's strength is in its mathematical content, which revives almost-forgotten theorems, includes new proofs, and is thorough but not overwhelmingly detailed or overburdened with notation."Journal of the American Statistical Association, June 2004From the reviews of the second edition:"This book may be considered as a monograph on probability modeling DNA sequence evolution. It also can be considered as reference book fro researchers in the theme. ... The book introduces the particularities of the modeling for special an important families of problems arising in the study of DNA. ... it is good book for mathematicians, biologists, physics, engineers and other scientists involved with the study of DNA problems." (Chou-la kain, Revista Investigación Operacional, Vol. 30 (2), 2009)"The highly acclaimed book ... by Richard Durrett also continues to be successful in the second edition. The book discusses probability models for population genetics focusing on analytical results and their proofs. ... A number of numerical examples and graphs are given to aid the reader's comprehension. ... The book can be highly recommended to all graduate students and researchers involved in interdisciplinary work in the field of mathematics and biology who are interested in genetics and evolution from a mathematical point of view." (Manuel Dehnert, Biometrical Journal, Vol. 51 (3), 2009)"This is the second edition of the author's book ... . One of its main aims is to build a bridge between biologists on the one hand, and mathematicians ... on the other hand. ... this edition has expanded a lot, almost doubling in size. This is mainly due to the fact that a lot of material has been added. ... One of the strong points of the book is that it is an excellent guide to the literature, collecting over 400 references ... ." (Jan M. Swart, Mathematical Reviews, Issue 2009 k)"The previous edition of this book was published in 2002 and reviewed in Biometrics 59, 206. The reviewer, David Balding, concluded that 'Both the mathematician looking for an introduction to applications in genetics, and the biologist needing more insight into the mathematical foundations of population genetics and evolution, will find much of interest here.' Those people will find even more of interest in this new edition, which is about 75% larger than the original. The expansion incorporates both an increase in the range of topics covered and an update in light of recent work." (Biometrics, Summer 2009, 65, 1000)

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