Opeyemi Osuntokun

Broschiertes Buch

Proanthocyanidin against convulsion and cognitive impairment

Effects of proanthocyanidin against seizure, cognitive-impairment, and convulsion-induced neuro-oxidative Stress

Beschreibung

Convulsive status epilepticus is arguably one of the most debilitating neurological disorder, characterized by prolong episode of seizures. It is worthy of note that brain diseases pose the largest health, economic, and social capital burden worldwide of any disease group. This study has explored the potential effects of proanthocyanidin rich fraction (PRF) obtained from grape seed on the central nervous system particularly in convulsive status epilepticus (CSE) model. In this study, a significant brain and hippocampus atrophy, increased malondialdehyde concentration, increased hippocampus glial cells and granule count, exacerbated activities of acetylcholinesterase and increased indices of neuroinflammation following CSE induction are consistent with the hippocampus-dependent memory impairment observed observed among the convulsed mice. However, most of these aberrations including alteration of cholinergic neurotransmitters, astrogliosis, hippocampus toxicity, neuroinflammation,and neuronal necrosis were ameliorated following PRF treatment, a result similar to what was obtainable in the group treated with a standard drug, diazepam.

Autor

I am passionate Neuroscientist and lecturer of Physiology having more than a decade experience, and global impact. My studies of Physiology from Bachelor's to Doctorate degree have deepened my understanding and skills in Biomedical Sciences, which have fostered my curiosity in the pathophysiology of epilepsy, and cognitive dysfunctions.

Produktdetails

• Verlag: Omniscriptum; Lap Lambert Academic Publishing
• Seitenzahl: 224
• Erscheinungstermin: 7. November 2025
• Englisch
• Abmessung: 220mm x 150mm x 14mm
• Gewicht: 352g
• ISBN-13: 9786209246135
• ISBN-10: 6209246133
• Artikelnr.: 75939938