PPAR Modulator
Peroxisome Proliferator-activated Receptor, GW501516, Clofibrate, Gemfibrozil, Diabetes Mellitus, Metabolic Syndrome
Herausgegeben: Dax, Indigo Theophanes
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. PPAR modulators are drugs which act upon the peroxisome proliferator-activated receptor.PPAR and PPAR are the molecular targets of a number of marketed drugs. The three main classes of PPAR drugs are: PPAR-alpha modulators:PPAR-alpha is the main target of fibrate drugs, a class of amphipathic carboxylic acids . They were originally indicated for cholesterol disorders (generally as an adjunctive to statins) and more recently for disorders that feature high triglyceride...
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. PPAR modulators are drugs which act upon the peroxisome proliferator-activated receptor.PPAR and PPAR are the molecular targets of a number of marketed drugs. The three main classes of PPAR drugs are: PPAR-alpha modulators:PPAR-alpha is the main target of fibrate drugs, a class of amphipathic carboxylic acids . They were originally indicated for cholesterol disorders (generally as an adjunctive to statins) and more recently for disorders that feature high triglycerides. Many of them increase the risk of cancer to the point where they eliminate the survival benefit of reduced heart disease.PPAR-delta modulators: PPAR-delta is the main target of a research chemical named GW501516. It has been shown that agonism of PPAR-delta changes the body's fuel preference from glucose to lipids, but ironically improves metabolic syndrome ). PPAR-gamma modulators:PPAR-gamma is the main target of the drug class of thiazolidinediones , used in diabetes mellitus and other diseases that
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