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Exploring the appropriate framework for flexible integration of services in B2B networks is challenging. Efficient data sharing requires a combination of techniques that utilizes the ubiquitous nature of SOA and data-driven interaction pattern provided by publish/subscribe. Integration of business processes and services need to leverage both stateful transactional data as well as stateless event-driven messages. This book presents a policy-based framework for event-driven data integration in B2B networks. This framework leverages SOA and publish/subscribe to overcome web service communication constraints. Important considerations to this architecture include communication patterns, security and privacy of data, distributed resource management, performance, and Quality of Service (QoS) for message delivery. An application scenario on Palliative Healthcare that uses the policy-based event-driven model to provide real-time monitoring of patient health status and the ability to provide timely and accurate interventions at emergencies is described. The focus is to support the dynamic nature of health care teams where team members and data usage is constantly changing and evolving.