
Pentavalent Antimonial
Leishmaniasis, Antimony, Sodium Stibogluconate, GlaxoSmithKline
Herausgegeben: Eyvindr, Lennox Raphael
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Pentavalent antimonials (also abbreviated pentavalent Sb or SbV) are a group of compounds used for the treatment of leishmaniasis. They are also called pentavalent antimony compounds.The first pentavalent antimonial used was urea stibamate: first introduced in the 1930s, it fell out of favour in the 1950s due to higher toxicity compared to sodium stibogluconate.The pentavalent antimonials can only be given by injection: there are no oral preparations available.In many countries, widespread resistance to antimony has meant that amphotericin or miltefosine are now used in preference.