Penitrem A
Neurotoxin, Ryegrass, Potassium Channel, Cerebellum
Herausgegeben: Parthalan, Ozzy R.
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Penitrem A (tremortin) is a fungal neurotoxin found on ryegrass. It is produced by certain species of Aspergillus, Claviceps, and Penicillium. It inhibits potassium channels in smooth muscles. The maxi-channels targeted have their highest density in the cerebellar Purkinje cells. It causes a stagger in horses and cattle. The ED50 for penitrem A is 10 nM. The ED50 is the effective dose for 50% of the population. Many toxic chemicals do not show ED-50s and act by irreversible covalent adduction.
