Path to Effective Recovering of DNA from Formalin-Fixed Biological Samples in Natural History Collections

Path to Effective Recovering of DNA from Formalin-Fixed Biological Samples in Natural History Collections

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Herausgeber: Tang, Evonne P y
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Museums catalogue our knowledge of the Earth's biodiversity, and their collections represent many decades of work by experts. Access to DNA sequence information in archival specimens would greatly extend knowledge of the genetic relationships within our biosphere. However, molecular genetic analysis of museum specimens has been slowed by the usual practice of fixation and storage of samples in formalin. Formalin is an environmental toxin and induces genetic and chromosomal alterations to the samples. Few of the many attempts to obtain and sequence DNA from formalin-fixed specimens stored in aq...