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Overcoming Solubility Challenges: A Strategy for Improving Bioavailability of Poorly Soluble Drugs with Self-Emulsifying Drug Delivery Systems
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The commercially feasible formulation strategy for this confront is self-emulsifying drug delivery systems (SEDDS). SEDDS are isotropic and thermodynamically stable mixtures of oil, surfactant, cosurfactant and drug that structure fine oil-in-water (o/w) emulsion on addition to aqueous phases with moderate agitation. Traditionally, SEDDS are formulated as liquid dosage forms that are administered as soft gelatin capsules, with constraints such as higher manufacture cost, incompatibility with excipients, lower drug stability, drug seepage and precipitation, lower drug loading, etc. The SEDDS fa...
The commercially feasible formulation strategy for this confront is self-emulsifying drug delivery systems (SEDDS). SEDDS are isotropic and thermodynamically stable mixtures of oil, surfactant, cosurfactant and drug that structure fine oil-in-water (o/w) emulsion on addition to aqueous phases with moderate agitation. Traditionally, SEDDS are formulated as liquid dosage forms that are administered as soft gelatin capsules, with constraints such as higher manufacture cost, incompatibility with excipients, lower drug stability, drug seepage and precipitation, lower drug loading, etc. The SEDDS facilitate larger interfacial area for partition of drug amongst oil and aqueous phase's, thus enhancing drug dissolution and bioavailability
