Olmesartan Loaded Solid Lipid Nanoparticles-Pharmacokinetics Studies

Olmesartan Loaded Solid Lipid Nanoparticles-Pharmacokinetics Studies

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Olmesartan medoxomil (OLM) , is a diphenyl tetrazole analogue belonging to the class of angiotensin II receptor antagonists which is used clinically in treatment of hypertension. It is practically insoluble in water and has oral bioavailability of 26%. Solid lipid nanoparticles (SLN), have been developed for various routes of administration with several objectives including enhancement of bioavailability of poor water soluble drugs. OLM loaded SLN formulation was prepared by hot homogenization and ultra-sonication method. The SLN formulations were characterized and optimized..In-vitro drug rel...