Octreotide
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Octreotide (brand name Sandostatin, Novartis Pharmaceuticals) is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone. It was first synthesized in 1979 by the chemist Wilfried Bauer. Since octreotide resembles somatostatin in physiological activities, it can: Inhibit secretion of many hormones, such as gastrin, cholecystokinin, glucagon, growth hormone,...
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Octreotide (brand name Sandostatin, Novartis Pharmaceuticals) is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone. It was first synthesized in 1979 by the chemist Wilfried Bauer. Since octreotide resembles somatostatin in physiological activities, it can: Inhibit secretion of many hormones, such as gastrin, cholecystokinin, glucagon, growth hormone, insulin, secretin, pancreatic polypeptide, TSH, and vasoactive intestinal peptide. Reduce secretion of fluids by the intestine and pancreas. Reduce gastrointestinal motility and inhibit contraction of the gallbladder. Inhibit the action of certain hormones from the anterior pituitary. Cause vasoconstriction in the blood vessels. Reduce portal vessel pressures in bleeding varices It has alsobeen shown to produce analgesic effects, most probably acting as a partial agonist at the mu opioid receptor.
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