NUMERICAL PDE ANALYSIS OF THE BLOOD BRAIN BARRIER
William E Schiesser
Gebundenes Buch

NUMERICAL PDE ANALYSIS OF THE BLOOD BRAIN BARRIER

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The remarkable functionality of the brain is made possible by the metabolism (chemical reaction) of oxygen (O¿) and nutrients in the brain. These metabolism components are supplied to the brain by an intricate blood circulatory system (vasculature). The blood brain barrier (BBB), which is the central topic of this book, determines the rate of transfer from the blood to the brain tissue. In particular, mathematical models are developed for mass transfer across the BBB based on partial differential equations (PDEs) applied to the blood capillaries, the endothelial membrane, and the brain tissue...