Novel Techniques to Enhance Bioavailability of Poorly Soluble Drugs

Novel Techniques to Enhance Bioavailability of Poorly Soluble Drugs

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Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately on the solubility of drug molecules. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation that produces pharmacological response. Currently only 8% of new drug candidates have both high solubility and permeability. Aqueous solubility of any therapeutically active substance is a key property; it governs dissolution, absorption and thus the In Vivo efficacy. For highly permeable and poorly soluble drug the rate of its oral absorption is often controlled by ...