Non-canonical pre-TCR signaling during T cell development
Damian Maseda Caballero
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Non-canonical pre-TCR signaling during T cell development

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T cells undergoing maturation in the thymus need to receive a pre-TCR-delivered signal to undergo ¿-selection and develop further properly. The pre-TCR is composed of a constitutively expressed pre-T¿ (pT¿) chain and a de novo expressed TCR¿ chain. A productive recombination of the TCR¿ chain is mandatory to overcome the first checkpoint that controls T cells survival. However, in a very low but consistent extent, thymocytes lacking a canonical pre-TCR can differentiate further. We show that thymocytes lacking a classical pre-TCR can survive and differentiate to later developmental stages...