Neurodegeneration: Current Research
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Neurodegeneration: Current Research

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Neurodegeneration refers to a progressive loss of function and structure of neurons. It is observed at different levels of neuronal circuitry from molecular to systemic. Several manifestations of neurodegeneration are amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease and Huntington's disease, among others. In the pursuit of effective therapies that can stop or reverse neurodegeneration, animal models of disease are being used to test potential therapeutic agents. These facilitate target identification and validation. Upregulation of autophagy and protein degradation are c...