Molecular Modeling and Synthesis of HBV Polymerase Inhibitors:

Molecular Modeling and Synthesis of HBV Polymerase Inhibitors:

Nucleoside and Non Nucleosides

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Hepatitis B virus (HBV) is the major cause of acute and chronic hepatitis which could lead to hepatocellular carcinoma. Currently, interferon- and nucleosidic inhibitors of HBV reverse transcriptase, polymerase, lamivudine (3TC), adefovir and entecavir are the only drugs approved for the treatment of chronic HBV infection. However, interferon- -produces many side affects with partial efficacy less than 30% of the chronic carriers responding to treatment. In addition, about 50% of the patients who respond positively to interferon- treatments are known to suffer recurrence of the viremia after c...