Molecular mechanisms of the effect of the mood stabilizer lithium
Annette Heinrich
Broschiertes Buch

Molecular mechanisms of the effect of the mood stabilizer lithium

On the mechanism of the effect of lithium on cAMP-induced CREB transcriptional activity

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Lithium salts are used to treat bipolar disorder, but the mechanisms accounting for the clinical efficacy are not completely understood. Chronic treatment with lithium is required to establish mood stabilization, suggesting the involvement of processes of neural plasticity. CREB (cAMP response element binding protein) is a transcription factor known to mediate neuronal adaptation. Recently, the CREB-coactivator TORC (transducer of regulated CREB) has been identified as a novel target of lithium. In the present study, several different methods were used to examine the molecular mechanism by whi...