Modulators of Nuclear Localization of the Human Enzyme ADAR1
Alexander Strehblow
Broschiertes Buch

Modulators of Nuclear Localization of the Human Enzyme ADAR1

DsRNA-binding domains of ADAR1

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The RNA editing enzyme hsADAR1 (human adenosine deaminase that acts on RNA 1) converts adenosines to inosines in double-stranded RNA and is a transcription-dependent shuttling protein. To enter the nucleus ADAR1 contains an atypical nuclear localization signal (NLS) overlapping the third double-stranded RNA binding domain (dsRBD) in the center of the enzyme. This study is concentrating on the characterization of the roles of dsRBD1 and 3 in the shuttling behavior of the enzyme. On the one hand our results indicate that NLS comprising residues are spread throughout the entire dsRBD. Additionall...