Broschiertes Buch

Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Order-Restricted Analysis of Microarray Data

Herausgegeben: Lin, Dan; Shkedy, Ziv; Yekutieli, Daniel; Amaratunga, Dhammika; Bijnens, Luc
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This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students.Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the poole...