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This study investigates how application of Hydrogen Release Compound (HRC ) might be implemented to remediate a site contaminated withtetrachloroethene (PCE) or its daughter products, under varying site conditions. The 3-D reactive transport model RT3D was coupled with a dual-Monodbiodegradation submodel to simulate the effect of the hydrogen generated by HRC on accelerating the biodegradation of dissolved chlorinated solvents.Varying site conditions and injection well configurations were investigated to determine the effect of these environmental and design conditions on overalltreatment efficiency.