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Spinosad (SPD) and imidacloprid (IM) belongs to bacterial and neonicotinoid insecticides respectively widely used in grain crop cultivation throughout the globe and more in India which may find their way into feed channel of livestock. To study the toxic effects of SPD and IM and its combination the present experiment was designed to observe the toxicopathological effects in broilers and its amelioration with vitamin E and silymarin.