Mitogen-activated protein kinase
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High Quality Content by WIKIPEDIA articles! Mitogen-activated protein MAP kinases EC 2.7.11.24 are serine, threonine-specific protein kinases that respond to extracellular stimuli mitogens, osmotic stress, heat shock and proinflammatory cytokines and regulate various cellular activities, such as gene expression, mitosis, differentiation, proliferation, and cell survival/apoptosis. They are activated within the protein kinase cascades called MAPK cascade . Each one consists of three enzymes, MAP kinase, MAP kinase kinase MKK, MEKK, or MAP2K and MAP kinase kinase kinase MKKK or MAP3K that are ac...
High Quality Content by WIKIPEDIA articles! Mitogen-activated protein MAP kinases EC 2.7.11.24 are serine, threonine-specific protein kinases that respond to extracellular stimuli mitogens, osmotic stress, heat shock and proinflammatory cytokines and regulate various cellular activities, such as gene expression, mitosis, differentiation, proliferation, and cell survival/apoptosis. They are activated within the protein kinase cascades called MAPK cascade . Each one consists of three enzymes, MAP kinase, MAP kinase kinase MKK, MEKK, or MAP2K and MAP kinase kinase kinase MKKK or MAP3K that are activated in series. A MAP3K that is activated by extracellular stimuli phosphorylates a MAP2K on its serine and threonine residues, and the this MAP2K activates a MAP kinase through phosphorylation on its serine and tyrosine residues Tyr-185 and Thr-183 of ERK2. In vivo and in vitro, phosphorylation of tyrosine precedes phosphorylation of threonine, although phosphorylation of either residue can occur in the absence of the other.
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