Kathrin Mählmann
Broschiertes Buch

Minimalistic immunologically defined gene expression T helper cell 1 (MIDGE-Th1®) vectors coding for Interleukin 12 and -18 in combination with the transfection agent SAINT-18 have systemic antitumoral effects on equine melanomas

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Equine melanomas are the most common neoplasms in older grey horses. Until now, no curative therapy is established. Xenogenic DNA vaccination represents a promising therapeutic approach. Goal of the present study was to evaluate the safety and clinical efficacy of vaccination of grey horses with natural occurring melanomas with MIDGE-Th1® vectors encoding for equine (eq) IL12 and eqILRAP-IL18 alone or in combination with human gp100 (hgp100) or human tyrosinase (htyr). Three groups (each n=9) of adult grey horses with variable numbers of melanomas received three intramuscular and three intrad...