Metronidazole Extended Release Solid Dosage Form

Metronidazole Extended Release Solid Dosage Form

Development of extended release formulation and in vitro bioequivalence study of Metronidazole solid dosage form

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Currently two effective ways are used with the administration of a metronidazole composition. A single, large dose is given as a bolus to the patient which is clinically effective but a major drawback to the administration of single large dose of metronidazole is the occurrence of significant and undesirable side effects. A second and more generally accepted treatment entails orally administering smaller dose of metronidazole three time a day. The lower dosage of metronidazole over a period of a week significantly reduces the occurrence and severity of side effect but patient compliance is a p...