Method development using Back-Scattering Interferometry
Bianca Schaffrath
Broschiertes Buch

Method development using Back-Scattering Interferometry

Analysis of binding between the adenosine A2A receptor and three selective antagonists

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Back-scattering interferometry is one of the latest technologies for the study and characterization of interactions between small molecules and more complex drug targets in a native-like environment without any labels or tethers. The information obtained with this technique is of great value since the conditions for the measurement are closest to the real conditions in the body. Principle of signal generation are conformational changes that occur during a binding event between a drug target and its ligand. In this project, the binding interaction between the adenosine A2A receptor and the thre...