Mesenchymal Stem Cell Aging: Implications for Cellular Cardiomyoplasty
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Mesenchymal Stem Cell Aging: Implications for Cellular Cardiomyoplasty

A Theoretical Exposition

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Cell-based therapy geared at the replacement of lost myocardial cells, and subsequent regeneration of damaged myocardial tissue is a viable and attractive therapeutic option. Bone Marrow derived Mesenchymal stem cells (BM-MSCs) have emerged in recent years as a practical and clinically relevant stem cell for the technique of cellular cardiomyoplasty. Enthusiasm for BM-MSCs is however tempered by evidence that cells from older donors show measurable and qualitative changes in their efficacy. This work provides a theoretical exposition on why BM-MSCs are a preferred cell source for cardiac regen...