Mechanisms of polymer matrix formation in sustained release tablets
Aleksandra Dumicic
Broschiertes Buch

Mechanisms of polymer matrix formation in sustained release tablets

Effects on drug release characteristics

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Although the problem of non-uniform, unpredictable matrices has been recently recognised, a limited number of literature reports deals with the problem, and without providing the mechanistic reasons for the variability in drug release characteristics. Identifying and understanding the main factors affecting the polymer matrix in the tablets is important to avoid intratablet and intrabatch variations in drug release rates, providing better systems in terms of safety/ efficacy, minimising risks of unexpected release of high amounts of drug (dose dumping). Matrix formation starts with application...