MBP Interacts with PIP2 at the Oligodendroglial Cell Membrane
Schanila Nawaz
Broschiertes Buch

MBP Interacts with PIP2 at the Oligodendroglial Cell Membrane

The Role of Phosphoinositides in the Interaction of Myelin Basic Protein with the Oligodendroglial Cell Membrane

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The only protein known to be essential for myelin formation and compaction in the central nervous system is myelin basic protein (MBP). The association of MBP as a positively-charged protein with negatively charged membranes is crucial for myelination, but the mechanisms by which MBP associates with the myelin membrane remains elusive. Here I demonstrate that the signaling lipid PIP2 is important for the stable association of MBP with cellular membranes. This association is lost upon specific decrease of membrane charges through selective hydrolyzation of PIP2 levels or through elevated intrac...