Matrix Metalloproteinases and Periodontal Disease
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The disease progression involves a network of interacting molecular pathways made of pro-inflammatory mediators like cytokines, growth factors, reactive oxygen species,matrix metalloproteinases (MMPs), and their inhibitors and regulators. Matrix macromolecules like proteoglycan and non- ollagen protein can be degraded by proteinases from the four major classes (metallo, serine, cysteine, and aspartic active site residues). Matrix metalloproteinases (MMPs) are members of a large subfamily of Zn 2+ and Ca 2+ dependent proteolytic enzymes, playinganimportant role in periodontal destruction.
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