m RNA purification: TECHNOLOGY ASPECTS and impurities

m RNA purification: TECHNOLOGY ASPECTS and impurities

TFF, Chromatography, UF/DF(Resins, magnetic beads, monoliths)

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m R.N.A. VACCINE production like other biopharmaceutical need various purification stages in the manifacturing process. In this process are used technique like: T.F.F., tangential flow filtration followed by different chromatografic procedure (affinity and ion exchange separation) with various kinds of resin an then UF/DF technique. (ultrafiltration -diafiltration). So it is of interest to verify the material used for this kind of procedure as solid phases or for the membrane and if released impurity in the final product. For Silica-based Reversed-Phase packings, a carbon load percentage indic...