Low weight gain as a predictor of retinopathy of prematurity
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Purposes: To analyze the low weight gain (WG) from birth to the sixth week of life as a risk factor for retinopathy of prematurity (ROP). Methods: A prospective cohort study comparing incidence of ROP and WG after preterm birth. Were included infants with birth weight (BW) 1,500 grams and gestational age 32 weeks at birth. Main clinical outcome were development of any stage and severe ROP. Main variable was the proportion of WG to the BW at the sixth week of life. Prevalence of ROP was determined and chi-square and Student-t test were used to compare data. Logistic regression was performed and...
Purposes: To analyze the low weight gain (WG) from
birth to the sixth week of life as a risk factor for
retinopathy of prematurity (ROP). Methods: A
prospective cohort study comparing incidence of ROP
and WG after preterm birth. Were included infants
with birth weight (BW) 1,500 grams and gestational
age 32 weeks at birth. Main clinical outcome were
development of any stage and severe ROP. Main
variable was the proportion of WG to the BW at the
sixth week of life. Prevalence of ROP was determined
and chi-square and Student-t test were used to
compare data. Logistic regression was performed and
the accuracy of WG for the development of ROP were
evaluated by receiver operating characteristic (ROC)
curves. Results: Of 317 studied preterms, 98 (30.9%)
developed ROP in any stage. Adjusted logistic
regression in Group 1 indicated 1.055 OR for ROP
(P0.001) and Group 2, 1.031 (P=0.007). The area
under the ROC curve for any stage ROP was 0.67%
(P0.001) and for severe ROP 0.63% (P=0.037).
Conclusions: Low WG measured by the 6th week of life
was an independent risk factor capable to predict
the development of any stage and severe ROP.
birth to the sixth week of life as a risk factor for
retinopathy of prematurity (ROP). Methods: A
prospective cohort study comparing incidence of ROP
and WG after preterm birth. Were included infants
with birth weight (BW) 1,500 grams and gestational
age 32 weeks at birth. Main clinical outcome were
development of any stage and severe ROP. Main
variable was the proportion of WG to the BW at the
sixth week of life. Prevalence of ROP was determined
and chi-square and Student-t test were used to
compare data. Logistic regression was performed and
the accuracy of WG for the development of ROP were
evaluated by receiver operating characteristic (ROC)
curves. Results: Of 317 studied preterms, 98 (30.9%)
developed ROP in any stage. Adjusted logistic
regression in Group 1 indicated 1.055 OR for ROP
(P0.001) and Group 2, 1.031 (P=0.007). The area
under the ROC curve for any stage ROP was 0.67%
(P0.001) and for severe ROP 0.63% (P=0.037).
Conclusions: Low WG measured by the 6th week of life
was an independent risk factor capable to predict
the development of any stage and severe ROP.
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