Liquisolid Technique. A boon for Solubility Enhancement
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As liquisolid tablets contain a drug dissolved in propylene glycol, the drug surface available for dissolution is highly increased. In short, drug is present in the form of molecular dispersion, after its disintegration in the dissolution media. Hence, molecularly dispersed drug in liquisolid tablets may be responsible for greater dissolution rates compared to marketed formulation. This will also reflect enhanced oral bioavailability. Also, it was previously proved that low drug concentration in liquid medication; more rapid drug release obtained. It was due to the fact that, drug in high conc...
As liquisolid tablets contain a drug dissolved in propylene glycol, the drug surface available for dissolution is highly increased. In short, drug is present in the form of molecular dispersion, after its disintegration in the dissolution media. Hence, molecularly dispersed drug in liquisolid tablets may be responsible for greater dissolution rates compared to marketed formulation. This will also reflect enhanced oral bioavailability. Also, it was previously proved that low drug concentration in liquid medication; more rapid drug release obtained. It was due to the fact that, drug in high concentration tend to precipitate within the silica pores (Aerosil 200). The dissolution profile of liquisolid tablets supports the above-mentioned hypothesis.
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