Intracellular ion channel 1 between neurogenesis and neurodegeneration
Stefania Averaimo
Broschiertes Buch

Intracellular ion channel 1 between neurogenesis and neurodegeneration

CLIC1 in neuronal physiology and pathology

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The cell cycle hypothesis for neurodegenerative diseases suggests a link between "cell cycle-like reactivation" and neuronal death, mainly in Alzheimer disease (AD), one of the most common neurodegenerative diseases for which an efficient treatment is yet to be identified. The insult represented by A deposits, a typical hallmark of AD, could force the neuron to re-enter the cell cycle. However, a highly differentiated cell unable to successfully accomplish a task normally attributable to immature cells, would end up in neuronal death. Considering neurodegeneration as a result of the abnormal a...