INTERACTIONS OF FLAVONES AND RELATED COMPOUNDS WITH NUCLEIC ACIDS
An approach to study interactions between natural compounds with nucleic acids and synthesis of flavonoid derivatives
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Across the world, different diseases have beentreated with herbal extracts, based on common andempiric knowledge. The process of identification ofthe active compounds and their synthesis,optimisation and development for new drug candidatesappropriate for clinical use is described asMedicinal Chemistry; a discipline merging chemistryand pharmacology. This monograph describes a group of activeingredients from herbal medicines, as a foundationfor the development of new anticancer drugs.Interactions between with genomic DNA, syntheticpolynucleotides and higher order DNA isoforms (tripleand quadrup...
Across the world, different diseases have been
treated with herbal extracts, based on common and
empiric knowledge. The process of identification of
the active compounds and their synthesis,
optimisation and development for new drug candidates
appropriate for clinical use is described as
Medicinal Chemistry; a discipline merging chemistry
and pharmacology.
This monograph describes a group of active
ingredients from herbal medicines, as a foundation
for the development of new anticancer drugs.
Interactions between with genomic DNA, synthetic
polynucleotides and higher order DNA isoforms (triple
and quadruple helical forms) have been studied.
Rational drug design has been also employed during
this project to elucidate the mode of binding and
novel compounds have been synthesized to provide
precise structure-activity related studies resulting
in a second generation of chemotherapeutic anticancer
agents with improved properties.
This book provides information and protocols for
studying drug-DNA interactions using spectroscopical
and biological techniques; synthesis of flavonoids
and the principles to explore the use of Quantitative
Structure Activity Relationship Studies.
treated with herbal extracts, based on common and
empiric knowledge. The process of identification of
the active compounds and their synthesis,
optimisation and development for new drug candidates
appropriate for clinical use is described as
Medicinal Chemistry; a discipline merging chemistry
and pharmacology.
This monograph describes a group of active
ingredients from herbal medicines, as a foundation
for the development of new anticancer drugs.
Interactions between with genomic DNA, synthetic
polynucleotides and higher order DNA isoforms (triple
and quadruple helical forms) have been studied.
Rational drug design has been also employed during
this project to elucidate the mode of binding and
novel compounds have been synthesized to provide
precise structure-activity related studies resulting
in a second generation of chemotherapeutic anticancer
agents with improved properties.
This book provides information and protocols for
studying drug-DNA interactions using spectroscopical
and biological techniques; synthesis of flavonoids
and the principles to explore the use of Quantitative
Structure Activity Relationship Studies.
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