Insulin Resistance and Nephropathy in Type 2 Diabetic Patients

Insulin Resistance and Nephropathy in Type 2 Diabetic Patients

Insulin Resistance and Specific Biomarkers in Blood and Urine of Type 2 Diabetic Patients with or without Nephropathy

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Diabetic nephropathy (DN) is a common and severe microvascular complication of type 2 diabetes mellitus (T2DM) that can result in end-stage renal disease (ESRD). On the other hand, insulin resistance (IR) is strongly associated with obesity and had an important role in the pathogenesis and increased complicating of many human diseases such as diabetes which can be used as a biomarker of renal dysfunction in DN thus decreasing the mortality and morbidity. Hence, taking into consideration the combination of obesity, IR and T2DM may demonstrated excellent indicator for early-stage DN in patients ...